Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.

PloS one - 1 Jan 2014

Richard Guy-Franck, Viterbo David, Khanna Varun, Mosbach Valentine, Castelain Lauriane, Dujon Bernard

Abstract excerpt

Trinucleotide repeat expansions are responsible for more than two dozens severe neurological disorders in humans. A double-strand break between two short CAG/CTG trinucleotide repeats was formerly shown to induce a high frequency of repeat contractions in yeast. Here, using a dedicated TALEN, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to Fungal Proteins
Share to Karyotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Share to Sequence Deletion

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 24748175
DOI: 10.1371/journal.pone.0095611
PMCID: PMC3991675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24748175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.PMID 24748175Read ↗

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats.Semantic proximity Read ↗

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cellsSemantic proximity Read ↗

Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.Semantic proximity Read ↗

Fourteen and counting: unraveling trinucleotide repeat diseasesSemantic proximity Read ↗

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.Semantic proximity Read ↗

Trinucleotide repeats: mechanisms and pathophysiology.Semantic proximity Read ↗

[Amplification of trinucleotide repeats--a new mutation mechanism causing common genetic diseases].Semantic proximity Read ↗

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangementsSemantic proximity Read ↗

The complex pathology of trinucleotide repeats.Semantic proximity Read ↗

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cellsSemantic proximity Read ↗

GTR 2.0: gRNA-tRNA Array and Cas9-NG Based Genome Disruption and Single-Nucleotide Conversion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Trinucleotide expansion in disease: why is there a length threshold?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.