Article

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangements

2019-09-25

Abstract excerpt

<h4>Summary</h4> Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ∼2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellites with dedicated DNA endonucleases could become a viable option for patients affected with dramatic neurodegenerative disorders. Here, we used the S...

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Literature Corpus work: e05253da-2b16-516a-bca1-9c2d2abd22b8
DOI: 10.1101/782268

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