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Article

Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p.

Molecular & general genetics : MGG - 1 Jun 1999

Schroeder A J, Chen X H, Xiao Z, Fitzgerald-Hayes M

Abstract excerpt

The yeast Srp1p protein functions as an import receptor for proteins bearing basic nuclear localization signals. Cse1p, the yeast homolog of mammalian CAS, recycles Srp1p back to the cytoplasm after import substrates have been released into the nucleoplasm. In this report we describe genetic interactions between SRP1 and CSE1. Results from genetic suppression and synthetic lethality studies demonstrate that these...

Topics

Amino Acid Sequence
Base Sequence
Fungal Proteins
Genes, Fungal
Genes, Lethal
Genotype
Nuclear Proteins
Nucleocytoplasmic Transport Proteins
Restriction Mapping
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Suppression, Genetic

Temperature

alpha Karyopherins

Source

Identifiers

PMID: 10394916
DOI: 10.1007/s004380050022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p.PMID 10394916Read ↗

Cse1p is involved in export of yeast importin alpha from the nucleus.Semantic proximity Read ↗

Importin/karyopherin protein family members required for mRNA export from the nucleus.Semantic proximity Read ↗

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast nuclear import receptor is required for mitosis.Semantic proximity Read ↗

Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.Semantic proximity Read ↗

Cse1l is essential for early embryonic growth and development.Semantic proximity Read ↗

Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport.Semantic proximity Read ↗

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