Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p.

Molecular & general genetics : MGG - 1 Jun 1999

Schroeder A J, Chen X H, Xiao Z, Fitzgerald-Hayes M

Abstract excerpt

The yeast Srp1p protein functions as an import receptor for proteins bearing basic nuclear localization signals. Cse1p, the yeast homolog of mammalian CAS, recycles Srp1p back to the cytoplasm after import substrates have been released into the nucleoplasm. In this report we describe genetic interactions between SRP1 and CSE1. Results from genetic suppression and synthetic lethality studies demonstrate that these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha Karyopherins
Share to Fungal Proteins
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Nucleocytoplasmic Transport Proteins

Share to Restriction Mapping

Share to Suppression, Genetic

Share to Temperature

Source

Identifiers

PMID: 10394916
DOI: 10.1007/s004380050022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p.PMID 10394916Read ↗

Cse1p is involved in export of yeast importin alpha from the nucleus.Semantic proximity Read ↗

Importin/karyopherin protein family members required for mRNA export from the nucleus.Semantic proximity Read ↗

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast nuclear import receptor is required for mitosis.Semantic proximity Read ↗

Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.Semantic proximity Read ↗

Cse1l is essential for early embryonic growth and development.Semantic proximity Read ↗

Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.