The yeast nuclear import receptor is required for mitosis.

doi:10.1073/pnas.92.17.7647

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Article

The yeast nuclear import receptor is required for mitosis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1995

Loeb J D, Schlenstedt G, Pellman D, Kornitzer D, Silver P A, Fink G R

Abstract excerpt

The nuclear import system is highly conserved among eukaryotes. Here we report the effects of a conditional mutation in SRP1, which encodes a Saccharomyces cerevisiae homolog of the vertebrate nuclear import receptor importin. Importin was isolated as a factor required for the initial targeting step of a nuclear import substrate to the nuclear envelope in a mammalian in vitro assay. We show that yeast Srp1 is...

Topics

Animals
Base Sequence
Cell Nucleus
DNA Primers
Genes, Fungal
Genes, Lethal
Genotype
Karyopherins
Mating Factor
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Nuclear Proteins

Peptides

Pheromones

Polymerase Chain Reaction

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 7644471
DOI: 10.1073/pnas.92.17.7647
PMCID: PMC41202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7644471-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The yeast nuclear import receptor is required for mitosis.PMID 7644471Read ↗

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus.Semantic proximity Read ↗

Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis.Semantic proximity Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.Semantic proximity Read ↗

Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p.Semantic proximity Read ↗

Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway.Semantic proximity Read ↗

Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.Semantic proximity Read ↗

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