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Article

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.

Cell - 26 Jul 1991

Matsumoto T, Beach D

Abstract excerpt

A fission yeast mutant is described in which the onset of mitosis is uncoupled from the completion of DNA replication. pim1 (premature initiation of mitosis) cells can undergo mitotic chromosome condensation and mitotic spindle formation without completion of S phase and without the cdc25 mitotic inducer. The M phase kinase is required for pim1-induced mitosis and becomes activated. pim1 encodes a homolog of the...

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Source

Identifiers

PMID: 1855255
DOI: 10.1016/0092-8674(91)90624-8

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.PMID 1855255Read ↗

Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events.Semantic proximity Read ↗

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.Semantic proximity Read ↗

Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase.Semantic proximity Read ↗

Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition.Semantic proximity Read ↗

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.Semantic proximity Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

The yeast SRM1 protein and human RCC1 protein share analogous functions.Semantic proximity Read ↗

The yeast nuclear import receptor is required for mitosis.Semantic proximity Read ↗

Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis.Semantic proximity Read ↗

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.Semantic proximity Read ↗

Dominant mutants identify new roles for p34cdc2 in mitosis.Semantic proximity Read ↗

mik1(+) G1-S transcription regulates mitotic entry in fission yeast.Semantic proximity Read ↗

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