Article
The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.
Genetics - 1 Jan 2009
Pulliam Kanika F, Fasken Milo B, McLane Laura M, Pulliam John V, Corbett Anita H
Abstract excerpt
There is significant evidence linking nucleocytoplasmic transport to cell cycle control. The budding yeast, Saccharomyces cerevisiae, serves as an ideal model system for studying transport events critical to cell cycle progression because the nuclear envelope remains intact throughout the cell cycle. Previous studies linked the classical nuclear localization signal (cNLS) receptor, importin-alpha/Srp1, to the...
Topics
- Active Transport, Cell Nucleus
- Cell Nucleus
- G1 Phase
- Genes, Suppressor
- Green Fluorescent Proteins
- Karyopherins
- Mutant Proteins
- Mutation
- Nuclear Localization Signals
- Plasmids
- S Phase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins