Article
Generation of multipurpose alleles for the functional analysis of the mouse genome.
Briefings in functional genomics & proteomics - 1 Mar 2006
Schnütgen Frank
Abstract excerpt
A novel generation of retroviral gene-trap vectors has been developed with the ability to induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional site-specific recombination systems, which can repair and re-induce the gene-trap mutations when activated in succession. After the gene-trap insertions are passaged into mice, this system enables the...
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