Generation of multipurpose alleles for the functional analysis of the mouse genome.

doi:10.1093/bfgp/ell009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Generation of multipurpose alleles for the functional analysis of the mouse genome.

Briefings in functional genomics & proteomics - 1 Mar 2006

Schnütgen Frank

Abstract excerpt

A novel generation of retroviral gene-trap vectors has been developed with the ability to induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional site-specific recombination systems, which can repair and re-induce the gene-trap mutations when activated in succession. After the gene-trap insertions are passaged into mice, this system enables the...

Topics

Alleles
Animals
Genetic Vectors
Genome
Mice
Mutation

Source

Open in PubMed

Identifiers

PMID: 16769672
DOI: 10.1093/bfgp/ell009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics