Article
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
Cell - 18 Nov 2005
Keogh Michael-Christopher, Kurdistani Siavash K, Morris Stephanie A, Ahn Seong Hoon, Podolny Vladimir, Collins Sean R, Schuldiner Maya, Chin Kayu, Punna Thanuja, Thompson Natalie J, Boone Charles, Emili Andrew, Weissman Jonathan S, Hughes Timothy R, Strahl Brian D, Grunstein Michael, Greenblatt Jack F, Buratowski Stephen, Krogan Nevan J
Abstract excerpt
The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two distinct complexes. The smaller complex, Rpd3C(S), shares Sin3 and Ume1 with Rpd3C(L) but contains the unique subunits Rco1 and Eaf3. Rpd3C(S) mutants exhibit phenotypes remarkably similar to those of Set2, a histone methyltransferase...
Topics
- Acetylation
- Acetyltransferases
- Amino Acid Sequence
- Cluster Analysis
- Cyclin-Dependent Kinases
- Down-Regulation
- Epistasis, Genetic
- Gene Deletion
- Gene Expression Regulation, Fungal