Article
Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America - 10 Feb 2004
Jazayeri Ali, McAinsh Andrew D, Jackson Stephen P
Abstract excerpt
There are two main pathways in eukaryotic cells for the repair of DNA double-strand breaks: homologous recombination and nonhomologous end joining. Because eukaryotic genomes are packaged in chromatin, these pathways are likely to require the modulation of chromatin structure. One way to achieve this is by the acetylation of lysine residues on the N-terminal tails of histones. Here we demonstrate that Sin3p and...
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