Article
Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders.
Carcinogenesis - 1 Jul 1999
Beckman L E, Van Landeghem G F, Sikström C, Wahlin A, Markevärn B, Hallmans G, Lenner P, Athlin L, Stenling R, Beckman L
Abstract excerpt
A number of genes are involved in iron metabolism, including the transferrin receptor (TFR) and haemochromatosis (HFE) genes. In previous investigations an increased risk for neoplastic disease has been observed in individuals homo- and heterozygous for hereditary haemochromatosis. The HFE wild-type gene product complexes with the transferrin receptor (TF) and two different HFE mutations (Cys282Tyr and His63Asp)...
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