Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.

doi:10.1158/1055-9965.EPI-05-0013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2005

Abraham Benny K, Justenhoven Christina, Pesch Beate, Harth Volker, Weirich Gregor, Baisch Christian, Rabstein Sylvia, Ko Yon-Dschun, Brüning Thomas, Fischer Hans-Peter, Haas Susanne, Brod Sandra, Oberkanins Christian, Hamann Ute, Brauch Hiltrud

Abstract excerpt

Iron overload has been noticed as a feature of human breast cancer. Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis. To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer, we analyzed 19 sequence variations at HFE, TFR1, TFR2, and FPN1 and compared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Germany

Share to Hemochromatosis

Share to Incidence

Share to Iron

Share to Logistic Models

Share to Menopause

Source

Open in PubMed

Identifiers

PMID: 15894659
DOI: 10.1158/1055-9965.EPI-05-0013

Genes

HFE
TFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.PMID 15894659Read ↗

HFE H63D mutation frequency shows an increase in Turkish women with breast cancer.Semantic proximity Read ↗

Identification of novel mutations in hemochromatosis genes by targeted next generation sequencing in Italian patients with unexplained iron overload.Semantic proximity Read ↗

HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin saturation in C282Y heterozygotes.Semantic proximity Read ↗

[Molecular genetics of hemochromatosis].Semantic proximity Read ↗

Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer.Semantic proximity Read ↗

Analysis of HFE and TFR2 mutations in selected blood donors with biochemical parameters of iron overload.Semantic proximity Read ↗

Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the nurses' health study II.Semantic proximity Read ↗

Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population.Semantic proximity Read ↗

Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.Semantic proximity Read ↗

Hemochromatosis gene (HFE) mutations and cancer riskSemantic proximity Read ↗

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.Semantic proximity Read ↗

Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.