Article
Mutations in the HFE gene and their interaction with exogenous risk factors in hepatocellular carcinoma.
Blood cells, molecules & diseases - 1 Jan 2000
Fargion S, Stazi M A, Fracanzani A L, Mattioli M, Sampietro M, Tavazzi D, Bertelli C, Patriarca V, Mariani C, Fiorelli G
Abstract excerpt
The possible role of iron in facilitating the development of liver cancer is still debated. The aims of this study were to define the prevalence of the mutations 845G --> A and 187C --> G (C282Y and H63D) in the HFE gene associated with hereditary hemochromatosis in Italian patients with hepatocellular carcinoma occurring in cirrhosis and to analyze the interaction between these mutations and other established...
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