Article
Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age.
International journal of cancer - 1 Jul 2009
Shi Zumin, Johnstone Daniel, Talseth-Palmer Bente A, Evans Tiffany-Jane, Spigelman Allan D, Groombridge Claire, Milward Elizabeth A, Olynyk John K, Suchy Janina, Kurzawski Grzegorz, Lubinski Jan, Scott Rodney J
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by germline mutations in DNA mismatch repair genes; however, variation in disease expression suggests that there are potential modifying factors. Polymorphisms of the HFE gene, which cause the iron overload disorder hereditary haemochromatosis, have been proposed as potential risk factors for the development of colorectal cancer (CRC). To...
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