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Article

Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands).

Cancer causes & control : CCC - 1 Aug 2003

van der A Daphne L, van der Hel Olga, Roest Mark, van der Schouw Yvonne T, van Gils Carla H, Marx Joannes J M, van Noord Paulus A H, Peeters Petra H M

Abstract excerpt

BACKGROUND & AIMS: Heterozygosity for the Cys282Tyr transition in the HFE-gene is associated with slightly increased iron levels and may therefore be a potential risk factor for colorectal cancer. METHODS: We studied the relationship between Cys282Tyr-heterozygosity and colorectal cancer using a...

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Source

Identifiers

PMID: 12948285
DOI: 10.1023/a:1024839528684

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12948285-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands).PMID 12948285Read ↗

No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation.Semantic proximity Read ↗

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.Semantic proximity Read ↗

High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression.Semantic proximity Read ↗

Cancer risk in HFE C282Y homozygotes: results from the HUNT 2 study.Semantic proximity Read ↗

A novel (Leu183Pro-)mutation in the HFE-gene co-inherited with the Cys282Tyr mutation in two unrelated Dutch hemochromatosis patients.Semantic proximity Read ↗

Hemochromatosis gene HFE Cys282Tyr mutation analysis in a cohort of Northeast German hospitalized patients supports assumption of a North to South allele frequency gradient throughout Germany.Semantic proximity Read ↗

Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer.Semantic proximity Read ↗

Prevalence of the Cys282Tyr and His63Asp HFE gene mutations in Spanish patients with hereditary hemochromatosis and in controls.Semantic proximity Read ↗

Genetic and metabolic factors are associated with increased hepatic iron stores in a selected population of p.Cys282Tyr heterozygotes.Semantic proximity Read ↗

HFE gene C282Y variant is associated with colorectal cancer in Caucasians: a meta-analysis.Semantic proximity Read ↗

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.Semantic proximity Read ↗

Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women.Semantic proximity Read ↗

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