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Article

Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.

International journal of cancer - 15 May 2011

Gannon Philippe O, Medelci Sanae, Le Page Cécile, Beaulieu Martin, Provencher Diane M, Mes-Masson Anne-Marie, Santos Manuela M

Abstract excerpt

Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system. Two frequent mutations in the HFE gene, H63D and C282Y, are associate...

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Share to Genetic Predisposition to Disease
Share to Genotype
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Membrane Proteins

Share to Neoplasms, Glandular and Epithelial

Share to Ovarian Neoplasms

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Source

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Identifiers

PMID: 20669231
DOI: 10.1002/ijc.25577
PMCID: PMC3312916

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20669231-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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