Article
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Oncogene - 23 Oct 2003
Takahashi Mami, Mutoh Michihiro, Shoji Yutaka, Kamanaka Yoshihisa, Naka Masao, Maruyama Takayuki, Sugimura Takashi, Wakabayashi Keiji
Abstract excerpt
Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-...
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