NF- <i>k</i> appa B regulates IL-1 <i>beta</i> transcription through a consensus NF- <i>k</i> appa B binding site and a nonconsensus CRE-like site.

Abstract excerpt

In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 subunit of NF-kappa B or by treatment of the cells with a combination of NF-kappa B inducers including LPS, PMA, and dibutyryl cyclic AMP (L+P+C) in U937 cells....

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