Article
Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.
Cancer research - 1 Jun 1997
Billadeau D, Liu P, Jelinek D, Shah N, LeBien T W, Van Ness B
Abstract excerpt
Although the underlying genetic defect in multiple myeloma is unknown, activating mutations in the N- and K-ras oncogenes are common. Recent studies have suggested that ras mutations are associated with disease progression. We have introduced an activated N-ras12, N-ras61, or K-ras12 cDNA into th...
Topics
- Apoptosis
- Bone Marrow Cells
- Cell Cycle
- Cell Division
- Cells, Cultured
- DNA
- Genes, ras
- Glucocorticoids
- Humans
- Interleukin-6
- Multiple Myeloma
- Mutation
- Recombination, Genetic
- Stromal Cells
- Transduction, Genetic
- Tumor Cells, Cultured