Article
Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.
Molecular and cellular biology - 1 Jul 1990
Zhang Y H, Lin J X, Vilcek J
Abstract excerpt
Using variable-length deletion constructs of the 5'-flanking region of the human interleukin-6 (IL-6) gene linked to the chloramphenicol acetyltransferase gene, we showed that the region from positions -109 to -50 mediated the bulk of the response to tumor necrosis factor (TNF) or interleukin-1 (...
Topics
- Base Sequence
- Binding Sites
- Chromosome Deletion
- Colforsin
- DNA-Binding Proteins
- Fibroblasts
- Genes, Regulator
- Humans
- Interleukin-1
- Interleukin-6
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Nuclear Proteins
- Sequence Homology, Nucleic Acid
- Transcription Factors
- Transcription, Genetic
- Tumor Necrosis Factor-alpha