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Article

Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony.

Biochemical and biophysical research communications - 15 Apr 2005

Watanabe Takehiro, Iizuka Yoko, Liang Yi-Qiang, Inomata Hyoe, Gotoda Takanari, Yanai Kazuyuki, Isobe Mitsuaki, Kato Norihiro

Abstract excerpt

The spontaneously hypertensive rat (SHR) is a model of human insulin resistance syndrome. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism have been mapped to an overlapping region of rat chromosome (RNO) RNO4 in SHR of the National Institute of Health colony, where a deletion in the Cd36 gene has been implicated as the causative mutation of insulin resistance. The present study...

Topics

Animals
CD36 Antigens
Chromosome Mapping
Chromosomes, Mammalian
Genetic Linkage
Genetic Predisposition to Disease
Insulin Resistance
Japan
Quantitative Trait Loci
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred SHR

Source

Identifiers

PMID: 15752738
DOI: 10.1016/j.bbrc.2005.02.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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