Article
p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans.
The Journal of cell biology - 14 Jun 1999
Wen C, Greenwald I
Abstract excerpt
Mutations in the Caenorhabditis elegans sel-9 gene elevate the activity of lin-12 and glp-1, which encode members of the LIN-12/NOTCH family of receptors. Sequence analysis indicates SEL-9 is one of several C. elegans p24 proteins. Allele-specific genetic interactions suggest that reducing sel-9 activity increases the activity of mutations altering the extracellular domains of LIN-12 or GLP-1. Reducing sel-9...
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