Article
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
Development (Cambridge, England) - 1 Sept 1998
Levitan D, Greenwald I
Abstract excerpt
Presenilins have been implicated in the development of Alzheimer's disease and in facilitating LIN-12/Notch activity. Here, we use genetic methods to explore the relationship between C. elegans LIN-12 and SEL-12 presenilin. Reducing sel-12 activity can suppress the effects of elevated lin-12 acti...
Topics
- Alleles
- Amyloid beta-Protein Precursor
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Communication
- Endoplasmic Reticulum
- Fluorescent Antibody Technique, Indirect
- Gene Expression Regulation, Developmental
- Golgi Apparatus
- Green Fluorescent Proteins
- Helminth Proteins
- Luminescent Proteins
- Membrane Proteins
- Receptors, Notch
- Recombinant Fusion Proteins