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Article

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Sept 1998

Levitan D, Greenwald I

Abstract excerpt

Presenilins have been implicated in the development of Alzheimer's disease and in facilitating LIN-12/Notch activity. Here, we use genetic methods to explore the relationship between C. elegans LIN-12 and SEL-12 presenilin. Reducing sel-12 activity can suppress the effects of elevated lin-12 activity when LIN-12 is activated by missense mutations but not when LIN-12 is activated by removal of the extracellular...

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PMID: 9716525
DOI: 10.1242/dev.125.18.3599

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Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.PMID 9716525Read ↗

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HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.Semantic proximity Read ↗

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