Article
SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.
Genetics - 1 Dec 1999
Fares H, Greenwald I
Abstract excerpt
Ligands present on neighboring cells activate receptors of the LIN-12/Notch family by inducing a proteolytic cleavage event that releases the intracellular domain. Mutations that appear to eliminate sel-5 activity are able to suppress constitutive activity of lin-12(d) mutations that are point mutations in the extracellular domain of LIN-12, but cannot suppress lin-12(intra), the untethered intracellular domain....
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