Article
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997
Li X, Greenwald I
Abstract excerpt
Mutant presenilins have been found to cause Alzheimer disease. Here, we describe the identification and characterization of HOP-1, a Caenorhabditis elegans presenilin that displays much more lower sequence identity with human presenilins than does the other C. elegans presenilin, SEL-12. Despite...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cloning, Molecular
- DNA, Complementary
- Female
- Genes, Lethal
- Genetic Complementation Test
- Helminth Proteins
- Humans
- Membrane Glycoproteins