Article
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000
Doyle T G, Wen C, Greenwald I
Abstract excerpt
LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell-cell interactions during development. The sel-8 gene had been identified previously in a screen for suppressors of a mutation that constitutively activates LIN-12. Here, we report that sel-8 is essential for lin-12- and glp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein. We postulate that SEL-8 serves...
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