Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene.

doi:10.1038/377351a0

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Article

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene.

Nature - 28 Sept 1995

Levitan D, Greenwald I

Abstract excerpt

The lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving c...

Topics

Alleles
Alzheimer Disease
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Conserved Sequence
DNA Primers
Female
Genes, Helminth
Helminth Proteins
Humans
Membrane Proteins
Molecular Sequence Data
Mutagenesis
Receptors, Notch
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7566091
DOI: 10.1038/377351a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7566091-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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