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Article

Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.

The Journal of biological chemistry - 25 Feb 2005

Lavelin Irena, Geiger Benjamin

Abstract excerpt

In the present study we characterize a novel RhoGAP protein (RC-GAP72) that interacts with actin stress fibers, focal adhesions, and cell-cell adherens junctions via its 185-amino acid C-terminal region. Overexpression of RC-GAP72 in fibroblasts induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. RC-GAP72 mutant truncated...

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Source

Identifiers

PMID: 15611138
DOI: 10.1074/jbc.M411990200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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