Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

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Article

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Apr 1993

Jalink K, Eichholtz T, Postma F R, van Corven E J, Moolenaar W H

Abstract excerpt

Lysophosphatidic acid (LPA) is a mitogenic phospholipid produced by certain activated cells and present in serum. LPA stimulates phospholipase C and inhibits adenylate cyclase in its target cells, apparently by activating a specific G-protein-coupled receptor. Here, we demonstrate that LPA causes transient rounding of N1E-115 and NG108-15 neuronal cells accompanied by growth cone collapse and retraction of...

Topics

Actins
Animals
Cell Differentiation
Cell Size
Cytoskeleton
Enzyme Activation
Lysophospholipids
Mice
Neurons
Phenotype
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins pp60(c-src)

Receptors, Cell Surface

Receptors, Thrombin

Signal Transduction

Thrombin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7684247

Genes

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7684247-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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