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Article

Cancer immune escape: MHC expression in primary tumours versus metastases

11 Sept 2019

Abstract excerpt

Tumours can escape T-cell responses by losing major histocompatibility complex (MHC)/ human leucocyte antigen (HLA) class I molecules. In the early stages of cancer development, primary tumours are composed of homogeneous HLA class I-positive cancer cells. Subsequently, infiltration of the tumour by T cells generates a vast diversity of tumour clones with different MHC class I expressions. A Darwinian type of...

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Identifiers

PMID: 31509607
DOI: 10.1111/imm.13114

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