Article
Loss of HLA haplotype in lung cancer cell lines: implications for immunosurveillance of altered HLA class I/II phenotypes in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 1999
Hiraki A, Kaneshige T, Kiura K, Ueoka H, Yamane H, Tanaka M, Harada M
Abstract excerpt
Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance. Genomic DNA of MHC class I/II molecules in seven lung cancer cell lines was investigated and compared with that in peripheral blood mononuclear cells. In three cell lines, OU-LC-A1, OU-LC-A2, and OU-LC-AS1, a loss of HLA haplotype was...
Topics
- Carcinoma, Non-Small-Cell Lung
- DNA
- HLA Antigens
- Haplotypes
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Immunologic Surveillance
- Lung Neoplasms
- Male