Article
In Situ Detection of Individual Classic MHC-I Gene Products in Cancer.
Cancer immunology research - 2 Apr 2025
Gonzalez-Ericsson Paula I, Opalenik Susan R, Sanchez Violeta, Palubinsky Amy M, Hanna Ann, Sun Xiaopeng, Ocampo Andres A, Garcia Guadalupe, Maldonado Leonel, Morante Zaida, Vidaurre Tatiana, Valencia Guillermo, Gomez Henry L, Sanders Melinda E, Kennedy Laura C, Phillips Elizabeth J, Balko Justin M
Abstract excerpt
Tumor-specific HLA class I expression is required for cytotoxic T-cell elimination of cancer cells expressing tumor-associated antigens or neoantigens. Cancers downregulate antigen presentation to avoid adaptive immunity. The highly polymorphic nature of the genes encoding these proteins, coupled with quaternary-structure changes after formalin fixation, complicates detection by IHC. In this study, we determined...
Topics
- Humans
- Female
- Histocompatibility Antigens Class I
- Breast Neoplasms
- Neoplasms
- Alleles
- Antigens, Neoplasm
- Immunohistochemistry
- Genes, MHC Class I