Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serotonin-6 receptor variant (C267T) and clinical response to clozapine.

Neuroreport - 26 Apr 1999

Yu Y W, Tsai S J, Lin C H, Hsu C P, Yang K H, Hong C J

Abstract excerpt

Clozapine is an effective atypical antipsychotic that has high affinity for serotonin type 6 receptors (5HT6). We tested the hypothesis that clinical response to clozapine in patients refractory to typical antipsychotic treatment is related to the genetic variant (C267T) of the 5HT6 receptors. Ninety-nine schizophrenic patients with a history of non-response to typical antipsychotics were included in the study....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Clozapine
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Point Mutation

Share to Psychotic Disorders

Share to Receptors, Serotonin

Share to Schizophrenia

Source

Identifiers

PMID: 10363930
DOI: 10.1097/00001756-199904260-00014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serotonin-6 receptor variant (C267T) and clinical response to clozapine.PMID 10363930Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders.Semantic proximity Read ↗

Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

Association study of the 5-HT6 receptor gene in schizophrenia.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia.Semantic proximity Read ↗

Novel polymorphism in the 5'-upstream region of the human 5-HT6 receptor gene and schizophrenia.Semantic proximity Read ↗

Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.Semantic proximity Read ↗

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.Semantic proximity Read ↗

Genetic variation of 5-HT2A receptor and response to clozapine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.