Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.

doi:10.1038/sj.mp.4000348

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Article

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.

Molecular psychiatry - 1 Jan 1998

Arranz M J, Munro J, Owen M J, Spurlock G, Sham P C, Zhao J, Kirov G, Collier D A, Kerwin R W

Abstract excerpt

Clozapine is a potent atypical antipsychotic which binds to a variety of neurotransmitter receptors including serotonin (5-HT) receptors. However, the precise neurochemical site of clozapine's therapeutic action is unknown. We hypothesize that genetic variation in the neurotransmitter receptors t...

Topics

Alleles
Antipsychotic Agents
Clozapine
Drug Resistance
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin
Reference Values
Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 9491814
DOI: 10.1038/sj.mp.4000348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9491814-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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