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Article

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.

Molecular psychiatry - 1 Jan 1998

Arranz M J, Munro J, Owen M J, Spurlock G, Sham P C, Zhao J, Kirov G, Collier D A, Kerwin R W

Abstract excerpt

Clozapine is a potent atypical antipsychotic which binds to a variety of neurotransmitter receptors including serotonin (5-HT) receptors. However, the precise neurochemical site of clozapine's therapeutic action is unknown. We hypothesize that genetic variation in the neurotransmitter receptors to which the drug binds may influence clozapine response. To test this hypothesis we genotyped a novel -1438-G/A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9491814
DOI: 10.1038/sj.mp.4000348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.PMID 9491814Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

Association between clozapine response and allelic variation in 5-HT2A receptor gene.Semantic proximity Read ↗

Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia.Semantic proximity Read ↗

Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine responseSemantic proximity Read ↗

Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response.Semantic proximity Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.Semantic proximity Read ↗

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.Semantic proximity Read ↗

Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations.Semantic proximity Read ↗

Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia.Semantic proximity Read ↗

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