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Article

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.

Neuroscience letters - 18 Oct 1996

Arranz M J, Collier D A, Munro J, Sham P, Kirov G, Sodhi M, Roberts G, Price J, Kerwin R W

Abstract excerpt

Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr...

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Source

Identifiers

PMID: 8916101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.PMID 8916101Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.Semantic proximity Read ↗

Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs.Semantic proximity Read ↗

Association between clozapine response and allelic variation in 5-HT2A receptor gene.Semantic proximity Read ↗

Genetic variation of 5-HT2A receptor and response to clozapine.Semantic proximity Read ↗

Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine responseSemantic proximity Read ↗

Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.Semantic proximity Read ↗

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.Semantic proximity Read ↗

Polymorphisms of serotonin neurotransmission and their effects on antipsychotic drug action.Semantic proximity Read ↗

Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations.Semantic proximity Read ↗

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