Article
Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.
Neuroscience letters - 18 Oct 1996
Arranz M J, Collier D A, Munro J, Sham P, Kirov G, Sodhi M, Roberts G, Price J, Kerwin R W
Abstract excerpt
Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targ...
Topics
- Alleles
- Antipsychotic Agents
- Clozapine
- DNA
- Genotype
- Humans
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Psychiatric Status Rating Scales
- Receptors, Serotonin
- Schizophrenia