Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.

Neuroreport - 29 Dec 1995

Sodhi M S, Arranz M J, Curtis D, Ball D M, Sham P, Roberts G W, Price J, Collier D A, Kerwin R W

Abstract excerpt

A cysteine to serine substitution at amino acid 23 in the 5-HT2C receptor gene alters the pharmacological properties of the protein. We investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between the disease state or clinical response to the atypical antipsychotic drug, clozapine. Ninety percent of subjects who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genotype

Share to Molecular Sequence Data

Share to Polymorphism, Genetic

Share to Prognosis

Source

Identifiers

PMID: 8742444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.PMID 8742444Read ↗

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.Semantic proximity Read ↗

Association between clozapine response and allelic variation in 5-HT2A receptor gene.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

Clozapine response and the 5HT2C Cys23Ser polymorphism.Semantic proximity Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response.Semantic proximity Read ↗

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.Semantic proximity Read ↗

Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia.Semantic proximity Read ↗

Genetic variation of 5-HT2A receptor and response to clozapine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.