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Article

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.

Neuroreport - 29 Dec 1995

Sodhi M S, Arranz M J, Curtis D, Ball D M, Sham P, Roberts G W, Price J, Collier D A, Kerwin R W

Abstract excerpt

A cysteine to serine substitution at amino acid 23 in the 5-HT2C receptor gene alters the pharmacological properties of the protein. We investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between...

Topics

Alleles
Antipsychotic Agents
Base Sequence
Case-Control Studies
Clozapine
Double-Blind Method
Genetic Variation
Genotype
Humans
Molecular Sequence Data
Polymorphism, Genetic
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Serotonin

Schizophrenia

Serotonin Antagonists

Treatment Outcome

Source

Identifiers

PMID: 8742444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8742444-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association between clozapine response and allelic variation in the 5-HT2C receptor gene.PMID 8742444Read ↗

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.Semantic proximity Read ↗

Association between clozapine response and allelic variation in 5-HT2A receptor gene.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

Clozapine response and the 5HT2C Cys23Ser polymorphism.Semantic proximity Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response.Semantic proximity Read ↗

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.Semantic proximity Read ↗

Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia.Semantic proximity Read ↗

Genetic variation of 5-HT2A receptor and response to clozapine.Semantic proximity Read ↗

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