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PTEN/MMAC1 Mutation and Frequent Loss of Heterozygosity Identified in Chromosome 10q in a Subset of Hepatocellular Carcinomas

1 Mar 2000

Abstract excerpt

Frequent allelic losses on chromosome 10q have been reported in several types of cancers, suggesting the presence of a putative tumor suppressor gene(s) on the chromosomal arm. We examined loss of heterozygosity (LOH) on chromosome 10q in 37 hepatocellular carcinomas (HCC) using eleven dinucleotide microsatellite markers, spanning the entire chromosome arm of 10q. Twelve (32%) out of 37 informative cases showed...

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PMID: 10760687
DOI: 10.1111/j.1349-7006.2000.tb00943.x

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PTEN/MMAC1 Mutation and Frequent Loss of Heterozygosity Identified in Chromosome 10q in a Subset of Hepatocellular CarcinomasPMID 10760687Read ↗

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.Semantic proximity Read ↗

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.Semantic proximity Read ↗

Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.Semantic proximity Read ↗

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Cluster of allele losses within a 2.5 cM region of chromosome 10 in high-grade invasive bladder cancer.Semantic proximity Read ↗

Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma.Semantic proximity Read ↗

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