Article
Rad24 truncation, coupled with altered telomere structure, promotes cdc13-1 suppression in S. cerevisiae.
Cell cycle (Georgetown, Tex.) - 1 Nov 2008
Small Vanessa Y, Chuang Charles, Nugent Constance I
Abstract excerpt
Distinguishing telomeres from DNA double strand breaks is critical for genome stability. In S. cerevisiae, the Cdc13 single-strand telomere binding protein is critical for protecting chromosome ends. The C-rich telomere strand is lost at high temperatures in cdc13-1 strains, leading to activation of the DNA damage checkpoint and cell inviability. Through a screen performed to identify activities involved in...
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