Article
p53 gene mutations are not required for early dissemination of cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999
Offner S, Schmaus W, Witter K, Baretton G B, Schlimok G, Passlick B, Riethmüller G, Pantel K
Abstract excerpt
The p53 protein is involved in several central cellular processes, including gene transcription, DNA repair, cell cycling, genomic stability, chromosomal segregation, senescence, and apoptosis. p53 mutations frequently result in an immunocytochemically detectable accumulation of the p53 protein in tumor cells. To evaluate whether p53 gene mutations are required for the onset of hematogeneous tumor cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.