Article
Serum p53 antibodies as early markers of lung cancer.
Nature medicine - 1 Jul 1995
Lubin R, Zalcman G, Bouchet L, Trédanel J, Legros Y, Cazals D, Hirsch A, Soussi T
Abstract excerpt
The p53 alteration is the most common alteration found in human cancer. It usually involves missense mutations that stabilize the p53 protein, which in turn accumulates, reaching levels detectable by immunohistochemistry. We and others have demonstrated that this overexpression of mutant p53 prot...
Topics
- Adult
- Antibodies, Neoplasm
- Antibody Specificity
- Antigens, Neoplasm
- Autoantibodies
- Biomarkers, Tumor
- Bronchial Neoplasms
- Carcinoma, Squamous Cell
- Genes, p53
- Humans
- Immunoglobulin G
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Smoking
- Tumor Suppressor Protein p53