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Article

p53 gene mutations in primary lung tumors are conserved in brain metastases.

Journal of neuro-oncology - 1 Oct 1992

Schlegel U, Rosenfeld M R, Volkenandt M, Rosenblum M, Dalmau J, Furneaux H

Abstract excerpt

The p53 product is frequently mutated in human tumors. Both acquired and inherited mutations have been described. These mutations transform p53 from a growth suppressor gene to a transforming oncogene. We examined tissue from 6 patients with primary lung carcinoma and the corresponding brain metastases for the presence of p53 mutations by immunohistochemistry. We then confirmed and characterized the mutations by...

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PMID: 1331352
DOI: 10.1007/BF00177612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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