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Article

p53 gene mutations in primary lung tumors are conserved in brain metastases.

Journal of neuro-oncology - 1 Oct 1992

Schlegel U, Rosenfeld M R, Volkenandt M, Rosenblum M, Dalmau J, Furneaux H

Abstract excerpt

The p53 product is frequently mutated in human tumors. Both acquired and inherited mutations have been described. These mutations transform p53 from a growth suppressor gene to a transforming oncogene. We examined tissue from 6 patients with primary lung carcinoma and the corresponding brain metastases for the presence of p53 mutations by immunohistochemistry. We then confirmed and characterized the mutations by...

Topics

Aged
Base Sequence
Brain Neoplasms
Carcinoma, Non-Small-Cell Lung
Codon
DNA Mutational Analysis
DNA, Neoplasm
Exons
Female
Genes, p53
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 1331352
DOI: 10.1007/BF00177612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1331352-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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