Article
Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.
Gastroenterology - 1 Jun 1999
Knolle P A, Schmitt E, Jin S, Germann T, Duchmann R, Hegenbarth S, Gerken G, Lohse A W
Abstract excerpt
BACKGROUND & AIMS: Murine liver sinusoidal endothelial cells (LSECs) constitutively express accessory molecules and can present antigen to memory Th1 CD4(+) T cells. Using a T-cell receptor transgenic mouse line, we addressed the question whether LSECs can prime naive CD4(+) T cells. METHODS: Purified LSECs were investigated for their ability to induce activation and differentiation of naive CD4(+) T cells in...
Topics
- Animals
- Antigen-Presenting Cells
- Biomarkers
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Cytokines
- Endothelium
- Female
- Gene Expression
- Interferon-gamma
- Interleukin-12