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Article

Functional responses of resident human T cells in intact liver tissue.

Cellular immunology - 1 Feb 2021

Hollingshead Nicole, Wu Xia, Kenerson Heidi, Chen Antony, Strickland Ian, Horton Helen, Yeung Raymond, Crispe Ian N

Abstract excerpt

The liver contains a rich mix of T cells, including activated T cells, tissue-resident memory T cells and cells undergoing apoptosis. When antigens are presented in this milieu the default result is functional tolerance. T cell tolerance in the liver could be constitutive, or it could be adaptive, in which case liver cells would become unresponsive after encountering antigen in the liver context. To test this...

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Source

Identifiers

PMID: 33421676
DOI: 10.1016/j.cellimm.2020.104275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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