Article
Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.
Hepatology (Baltimore, Md.) - 1 Jan 2008
Diehl Linda, Schurich Anna, Grochtmann Regina, Hegenbarth Silke, Chen Lieping, Knolle Percy A
Abstract excerpt
UNLABELLED: Liver sinusoidal endothelial cells (LSEC) are unique organ-resident antigen-presenting cells capable of cross-presentation and subsequent tolerization of naïve CD8(+) T cells. We investigated the molecular mechanisms underlying this tolerance induction in naive CD8(+) T cells. MHC class I-restricted antigen presentation by LSEC led to initial stimulation of naïve CD8(+) T cells, which up-regulated...
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