Article
Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants.
Scientific reports - 22 Jan 2016
Xu Xi, Jin Rong, Li Mingyang, Wang Ke, Zhang Shusong, Hao Jie, Sun Xiuyuan, Zhang Yu, Wu Hounan, Zhang Jun, Ge Qing
Abstract excerpt
The liver is a unique lymphoid organ whose microenvironment is biased towards tolerance induction. We previously found that a proportion of CD4(+) autoreactive recent thymic emigrants (RTEs) retained in the liver after thymic egress and acquired IL-10 producing capability. To investigate the tolerance of these liver persisting CD4(+) RTEs in more detail and to study the liver stromal cell types that facilitate...
Topics
- Animals
- Apoptosis
- CD4-Positive T-Lymphocytes
- Cell Communication
- Endothelial Cells
- Immune Tolerance
- Liver
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- Receptors, Notch
- Signal Transduction
- Thymus Gland