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Article

Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain.

Biochemistry - 11 Oct 2005

Stephens Gena E, Slawson Elizabeth E, Craig Carolyn A, Elgin Sarah C R

Abstract excerpt

Heterochromatin Protein 2 (HP2) is a nonhistone chromosomal protein from Drosophila melanogaster localized principally in the pericentric heterochromatin, telomeres, and fourth chromosome, all regions associated with HP1. Mutations in HP2 can suppress position effect variegation, indicating a role in gene silencing and heterochromatin formation [Shaffer, C. D. et al. (2002) Proc. Natl. Acad. Sci.U.S.A. 99,...

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Identifiers

PMID: 16201764
DOI: 10.1021/bi051006+
PMCID: PMC2534139

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Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain.PMID 16201764Read ↗

The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure.Semantic proximity Read ↗

Heterochromatin protein 2 interacts with Nap-1 and NURF: a link between heterochromatin-induced gene silencing and the chromatin remodeling machinery in Drosophila.Semantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers.Semantic proximity Read ↗

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Semantic proximity Read ↗

The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1.Semantic proximity Read ↗

Investigation into the role of heterochromatin protein 1 gamma (HP1γ) in gene regulation in mammalsSemantic proximity Read ↗

Phosphorylation of heterochromatin protein 1 by casein kinase II is required for efficient heterochromatin binding in Drosophila.Semantic proximity Read ↗

Heterochromatin protein 1 is recruited to various types of DNA damage.Semantic proximity Read ↗

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.Semantic proximity Read ↗

Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.Semantic proximity Read ↗

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.Semantic proximity Read ↗

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