Article
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.
Molecular cell - 6 Jun 2013
Liu Huadong, Galka Marek, Mori Eiichiro, Liu Xuguang, Lin Yu-Fen, Wei Ran, Pittock Paula, Voss Courtney, Dhami Gurpreet, Li Xing, Miyaji Masaaki, Lajoie Gilles, Chen Benjamin, Li Shawn Shun-Cheng
Abstract excerpt
Lysine methylation occurs on both histone and nonhistone proteins. However, our knowledge on the prevalence and function of nonhistone protein methylation is poor. We describe an approach that combines peptide array, bioinformatics, and mass spectrometry to systematically identify lysine methylation sites and map methyllysine-driven protein-protein interactions. Using this approach, we identified a...
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