Article
The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.
Genetics - 1 Jun 1992
Eissenberg J C, Morris G D, Reuter G, Hartnett T
Abstract excerpt
Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to reflect the spreading of a heterochromatic structure into neighboring euchromatin. Two allelic dominan...
Topics
- Alleles
- Animals
- Chromobox Protein Homolog 5
- Chromosomal Proteins, Non-Histone
- DNA
- Drosophila melanogaster
- Epistasis, Genetic
- Gene Expression Regulation
- Genes, Lethal
- Genes, Suppressor
- Heterochromatin
- Mutation
- Recombinant Fusion Proteins