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Article

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

Genetics - 1 Jun 1992

Eissenberg J C, Morris G D, Reuter G, Hartnett T

Abstract excerpt

Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to reflect the spreading of a heterochromatic structure into neighboring euchromatin. Two allelic dominant suppressors of position-effect variegation were found to contain mutations within the gene encoding the...

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Identifiers

PMID: 1644277
DOI: 10.1093/genetics/131.2.345
PMCID: PMC1205009

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The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.PMID 1644277Read ↗

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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.Semantic proximity Read ↗

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Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Semantic proximity Read ↗

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Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.Semantic proximity Read ↗

Investigation into the role of heterochromatin protein 1 gamma (HP1γ) in gene regulation in mammalsSemantic proximity Read ↗

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Semantic proximity Read ↗

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