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Assessment of genetic changes and neurovirulence of shed Sabin and novel type 2 oral polio vaccine viruses

29 Jul 2021

Abstract excerpt

Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential to cause outbreaks. Two novel type 2 OPV (nOPV2) candidates were designed to stabilize the genome against the rapid reversion that is observed following vaccination with Sabin OPV type 2 (mOPV2). Next-generation sequencing...

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PMID: 34326330
DOI: 10.1038/s41541-021-00355-y

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