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Article

A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.

Biochemical and biophysical research communications - 10 May 1999

Okuyama Y, Ishiguro H, Toru M, Arinami T

Abstract excerpt

The human dopamine D4 receptor gene (DRD4) is an important candidate gene for schizophrenia. We identified a novel -521C>T polymorphism in the 5'-promoter region of DRD4. A transient expression method revealed that the T allele of this polymorphism reduces the transcriptional efficiency by 40% compared with the C allele. This polymorphism is of interest because of reported elevation of D4-like sites and DRD4 mRNA...

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Source

Identifiers

PMID: 10329380
DOI: 10.1006/bbrc.1999.0630

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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