Article
Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population.
Schizophrenia research - 1 Mar 2008
Monakhov Mikhail, Golimbet Vera, Abramova Lilia, Kaleda Vasily, Karpov Vadim
Abstract excerpt
Polymorphisms in the dopamine D2 receptor gene (DRD2) have repeatedly been associated with schizophrenia. Recently, the C957T polymorphism (rs6277), which alters mRNA stability and dopamine-induced upregulation of DRD2 expression in cell cultures and DRD2 mRNA translation in vitro, was tested for an association with the disease. Frequency of the C allele, corresponding to a normal wild-type level of expression,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
